HD-CAB: a cognitive assessment battery for clinical trials in Huntington's disease 1,2,3.
Identifieur interne : 000564 ( Main/Exploration ); précédent : 000563; suivant : 000565HD-CAB: a cognitive assessment battery for clinical trials in Huntington's disease 1,2,3.
Auteurs : Julie C. Stout [Australie] ; Sarah Queller ; Kalyca N. Baker ; Sean Cowlishaw ; Cristina Sampaio ; Cheryl Fitzer-Attas ; Beth BorowskySource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- complications : Huntington Disease.
- diagnosis : Cognition Disorders.
- etiology : Cognition Disorders.
- Adult, Analysis of Variance, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Reproducibility of Results, Time Factors.
Abstract
Cognitive dysfunction is central to Huntington's disease (HD) and undermines quality of life. Clinical trials are now targeting cognitive outcomes in HD; however, no cognitive battery has been optimized for HD clinical trials. We evaluated 16 cognitive tests in a 20-site, five-country, observational study designed to mimic aspects of a clinical trial (e.g., data collection managed by a contract research organization, repeated testing, prespecified statistical analyses). Fifty-five early HD, 103 premanifest HD (pre-HD), and 105 controls were tested at visit 1, visit 2 (1-3 days later), and visit 3 (5-7 weeks after visit 1). For inclusion in a recommended battery, tests were evaluated for sensitivity, practice effects, reliability, domain coverage, feasibility, and tolerability. Most tests differentiated controls from pre-HD and early HD and showed excellent psychometric properties. We selected six tests to constitute the Huntington's Disease Cognitive Assessment Battery (HD-CAB): Symbol Digit Modalities Test, Paced Tapping, One Touch Stockings of Cambridge (abbreviated), Emotion Recognition, Trail Making B, and the Hopkins Verbal Learning Test. These tests demonstrated sensitivity to disease status (Cohen's d effect sizes: early HD= -1.38 to -1.90 and pre-HD= -0.41 to -0.78), and acceptable reliability (r's 0.73-0.93). A composite score yielded large effect sizes (early HD = -2.44 and pre-HD = -0.87) and high reliability (r = 0.95). HD-CAB is the first cognitive battery designed specifically for use in late premanifest and early HD clinical trials. Adoption of the HD-CAB will facilitate evaluation of treatments to improve cognition in HD.
DOI: 10.1002/mds.25964
PubMed: 25209258
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000395
- to stream PubMed, to step Curation: 000395
- to stream PubMed, to step Checkpoint: 000574
- to stream Ncbi, to step Merge: 004108
- to stream Ncbi, to step Curation: 004108
- to stream Ncbi, to step Checkpoint: 004108
- to stream Main, to step Merge: 000564
- to stream Main, to step Curation: 000564
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">HD-CAB: a cognitive assessment battery for clinical trials in Huntington's disease 1,2,3.</title><author><name sortKey="Stout, Julie C" sort="Stout, Julie C" uniqKey="Stout J" first="Julie C" last="Stout">Julie C. Stout</name><affiliation wicri:level="1"><nlm:affiliation>School of Psychological Sciences, Monash University, Clayton, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Psychological Sciences, Monash University, Clayton, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Queller, Sarah" sort="Queller, Sarah" uniqKey="Queller S" first="Sarah" last="Queller">Sarah Queller</name></author><author><name sortKey="Baker, Kalyca N" sort="Baker, Kalyca N" uniqKey="Baker K" first="Kalyca N" last="Baker">Kalyca N. Baker</name></author><author><name sortKey="Cowlishaw, Sean" sort="Cowlishaw, Sean" uniqKey="Cowlishaw S" first="Sean" last="Cowlishaw">Sean Cowlishaw</name></author><author><name sortKey="Sampaio, Cristina" sort="Sampaio, Cristina" uniqKey="Sampaio C" first="Cristina" last="Sampaio">Cristina Sampaio</name></author><author><name sortKey="Fitzer Attas, Cheryl" sort="Fitzer Attas, Cheryl" uniqKey="Fitzer Attas C" first="Cheryl" last="Fitzer-Attas">Cheryl Fitzer-Attas</name></author><author><name sortKey="Borowsky, Beth" sort="Borowsky, Beth" uniqKey="Borowsky B" first="Beth" last="Borowsky">Beth Borowsky</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="doi">10.1002/mds.25964</idno><idno type="RBID">pubmed:25209258</idno><idno type="pmid">25209258</idno><idno type="wicri:Area/PubMed/Corpus">000395</idno><idno type="wicri:Area/PubMed/Curation">000395</idno><idno type="wicri:Area/PubMed/Checkpoint">000574</idno><idno type="wicri:Area/Ncbi/Merge">004108</idno><idno type="wicri:Area/Ncbi/Curation">004108</idno><idno type="wicri:Area/Ncbi/Checkpoint">004108</idno><idno type="wicri:Area/Main/Merge">000564</idno><idno type="wicri:Area/Main/Curation">000564</idno><idno type="wicri:Area/Main/Exploration">000564</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">HD-CAB: a cognitive assessment battery for clinical trials in Huntington's disease 1,2,3.</title><author><name sortKey="Stout, Julie C" sort="Stout, Julie C" uniqKey="Stout J" first="Julie C" last="Stout">Julie C. Stout</name><affiliation wicri:level="1"><nlm:affiliation>School of Psychological Sciences, Monash University, Clayton, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Psychological Sciences, Monash University, Clayton, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Queller, Sarah" sort="Queller, Sarah" uniqKey="Queller S" first="Sarah" last="Queller">Sarah Queller</name></author><author><name sortKey="Baker, Kalyca N" sort="Baker, Kalyca N" uniqKey="Baker K" first="Kalyca N" last="Baker">Kalyca N. Baker</name></author><author><name sortKey="Cowlishaw, Sean" sort="Cowlishaw, Sean" uniqKey="Cowlishaw S" first="Sean" last="Cowlishaw">Sean Cowlishaw</name></author><author><name sortKey="Sampaio, Cristina" sort="Sampaio, Cristina" uniqKey="Sampaio C" first="Cristina" last="Sampaio">Cristina Sampaio</name></author><author><name sortKey="Fitzer Attas, Cheryl" sort="Fitzer Attas, Cheryl" uniqKey="Fitzer Attas C" first="Cheryl" last="Fitzer-Attas">Cheryl Fitzer-Attas</name></author><author><name sortKey="Borowsky, Beth" sort="Borowsky, Beth" uniqKey="Borowsky B" first="Beth" last="Borowsky">Beth Borowsky</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Analysis of Variance</term><term>Cognition Disorders (diagnosis)</term><term>Cognition Disorders (etiology)</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Huntington Disease (complications)</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Reproducibility of Results</term><term>Time Factors</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Analysis of Variance</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Reproducibility of Results</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cognitive dysfunction is central to Huntington's disease (HD) and undermines quality of life. Clinical trials are now targeting cognitive outcomes in HD; however, no cognitive battery has been optimized for HD clinical trials. We evaluated 16 cognitive tests in a 20-site, five-country, observational study designed to mimic aspects of a clinical trial (e.g., data collection managed by a contract research organization, repeated testing, prespecified statistical analyses). Fifty-five early HD, 103 premanifest HD (pre-HD), and 105 controls were tested at visit 1, visit 2 (1-3 days later), and visit 3 (5-7 weeks after visit 1). For inclusion in a recommended battery, tests were evaluated for sensitivity, practice effects, reliability, domain coverage, feasibility, and tolerability. Most tests differentiated controls from pre-HD and early HD and showed excellent psychometric properties. We selected six tests to constitute the Huntington's Disease Cognitive Assessment Battery (HD-CAB): Symbol Digit Modalities Test, Paced Tapping, One Touch Stockings of Cambridge (abbreviated), Emotion Recognition, Trail Making B, and the Hopkins Verbal Learning Test. These tests demonstrated sensitivity to disease status (Cohen's d effect sizes: early HD= -1.38 to -1.90 and pre-HD= -0.41 to -0.78), and acceptable reliability (r's 0.73-0.93). A composite score yielded large effect sizes (early HD = -2.44 and pre-HD = -0.87) and high reliability (r = 0.95). HD-CAB is the first cognitive battery designed specifically for use in late premanifest and early HD clinical trials. Adoption of the HD-CAB will facilitate evaluation of treatments to improve cognition in HD.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Baker, Kalyca N" sort="Baker, Kalyca N" uniqKey="Baker K" first="Kalyca N" last="Baker">Kalyca N. Baker</name><name sortKey="Borowsky, Beth" sort="Borowsky, Beth" uniqKey="Borowsky B" first="Beth" last="Borowsky">Beth Borowsky</name><name sortKey="Cowlishaw, Sean" sort="Cowlishaw, Sean" uniqKey="Cowlishaw S" first="Sean" last="Cowlishaw">Sean Cowlishaw</name><name sortKey="Fitzer Attas, Cheryl" sort="Fitzer Attas, Cheryl" uniqKey="Fitzer Attas C" first="Cheryl" last="Fitzer-Attas">Cheryl Fitzer-Attas</name><name sortKey="Queller, Sarah" sort="Queller, Sarah" uniqKey="Queller S" first="Sarah" last="Queller">Sarah Queller</name><name sortKey="Sampaio, Cristina" sort="Sampaio, Cristina" uniqKey="Sampaio C" first="Cristina" last="Sampaio">Cristina Sampaio</name></noCountry><country name="Australie"><noRegion><name sortKey="Stout, Julie C" sort="Stout, Julie C" uniqKey="Stout J" first="Julie C" last="Stout">Julie C. Stout</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000564 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000564 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:25209258
|texte= HD-CAB: a cognitive assessment battery for clinical trials in Huntington's disease 1,2,3.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25209258" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |